3 years ago

Direct Access to N-Unprotected α- and/or β-Tetrasubstituted Amino Acid Esters via Direct Catalytic Mannich-Type Reactions Using N-Unprotected Trifluoromethyl Ketimines

Direct Access to N-Unprotected α- and/or β-Tetrasubstituted Amino Acid Esters via Direct Catalytic Mannich-Type Reactions Using N-Unprotected Trifluoromethyl Ketimines
Masanao Sawa, Kazuhiro Morisaki, Yuta Kondo, Hiroyuki Morimoto, Takashi Ohshima
A new wind blowing: The use of N-unprotected trifluoromethyl ketimines as effective electrophiles in direct catalytic Mannich-type reactions is reported, giving direct access to N-unprotected α- and/or β-tetrasubstituted amino acid esters under proton-transfer conditions. The first stereoselective construction of vicinal tetrasubstituted carbon stereocenters with N-unprotected ketimines is also presented. More information can be found in the Full Paper by H. Morimoto and T. Ohshima et al. (DOI: 10.1002/chem.201703516).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201704439

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