5 years ago

Tumor-Targeted and Clearable Human Protein-Based MRI Nanoprobes

Tumor-Targeted and Clearable Human Protein-Based MRI Nanoprobes
Gang Han, Jinyi Yang, Jing Peng, Yuanjie Niu, Shaokuan Zheng, Kai Huang, Ling Huang, Hewen Li, Jingjin Li, Xuening Zhang, Yang Zhao, Ning Jiang
Biocompatibility, targeting, and clearance are key challenges in the design of new MRI contrast agents. Herein, we report on a tumor-targeting, gadolinium biomineralized human transferrin (Tf) protein-based nanoparticle (Gd@Tf NP) for MRI use. As compared to the conventionally used gadolinium chelates, the resultant Gd@Tf NPs possess outstanding chemical stability and exhibited superior longitudinal relaxation. More importantly, our MR images show that Gd@Tf indeed retained the natural tumor targeting ability and the subsequent tumor retrieval biofunctions of Tf. Thus, such Tf protein-based MR NPs integrate T1 signal amplification, precise tumor targeting, and systematic clearance capabilities. They offer a new approach to design biocompatible multifunctional MRI contrast agents for a wide range of clinical imaging and treatment applications.

Publisher URL: http://dx.doi.org/10.1021/acs.nanolett.7b00828

DOI: 10.1021/acs.nanolett.7b00828

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