3 years ago

Association of Evidence-Based Care Processes and Mortality in Staphylococcus aureus Bacteremia

Schweizer ML, Goto M, et al., Vaughan-Sarrazin MS


Staphylococcus aureusbacteremia is common and frequently associated with poor outcomes. Evidence indicates that specific care processes are associated with improved outcomes for patients withS aureusbacteremia, including appropriate antibiotic prescribing, use of echocardiography to identify endocarditis, and consultation with infectious diseases (ID) specialists. Whether use of these care processes has increased in routine care forS aureusbacteremia or whether use of these processes has led to large-scale improvements in survival is unknown.


To examine the association of evidence-based care processes in routine care forS aureusbacteremia with mortality.

Design, Setting, and Participants

This retrospective observational cohort study examined all patients admitted to Veterans Health Administration (VHA) acute care hospitals who had a first episode ofS aureusbacteremia from January 1, 2003, through December 31, 2014.


Use of appropriate antibiotic therapy, echocardiography, and ID consultation.

Main Outcomes and Measures

Thirty-day all-cause mortality.


Analyses included 36 868 patients in 124 hospitals (mean [SD] age, 66.4 [12.5] years; 36 036 [97.7%] male), including 19 325 (52.4%) with infection due to methicillin-resistantS aureusand 17 543 (47.6%) with infection due to methicillin-susceptibleS aureus. Risk-adjusted mortality decreased from 23.5% (95% CI, 23.3%-23.8%) in 2003 to 18.2% (95% CI, 17.9%-18.5%) in 2014. Rates of appropriate antibiotic prescribing increased from 2467 (66.4%) to 1991 (78.9%), echocardiography from 1256 (33.8%) to 1837 (72.8%), and ID consultation from 1390 (37.4%) to 1717 (68.0%). After adjustment for patient characteristics, cohort year, and other care processes, receipt of care processes was associated with lower mortality, with adjusted odds ratios of 0.74 (95% CI, 0.68-0.79) for appropriate antibiotics, 0.73 (95% CI, 0.68-0.78) for echocardiography, and 0.61 (95% CI, 0.56-0.65) for ID consultation. Mortality decreased progressively as the number of care processes that a patient received increased (adjusted odds ratio for all 3 processes compared with none, 0.33; 95% CI, 0.30-0.36). An estimated 57.3% (95% CI, 48.4%-69.9%) of the decrease in mortality between 2003 and 2014 could be attributed to increased use of these evidence-based care processes.

Conclusions and Relevance

Mortality associated withS aureusbacteremia decreased significantly in VHA hospitals, and a substantial portion of the decreasing mortality may have been attributable to increased use of evidence-based care processes. The experience in VHA hospitals demonstrates that increasing application of these care processes may improve survival among patients withS aureusbacteremia in routine health care settings.

Publisher URL: http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2652832

DOI: 10.1001/jamainternmed.2017.3958

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