Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Consecutive Sonogashira Coupling and Hydroamination Cyclization for the Synthesis of Isoindolo[1,2-b]quinazolin-10(12H)-ones Catalyzed by CuI/l-Proline

Consecutive Sonogashira Coupling and Hydroamination Cyclization for the Synthesis of Isoindolo[1,2-b]quinazolin-10(12H)-ones Catalyzed by CuI/l-Proline
Jian-Quan Liu, Mei-Mei Zhang, Xiang-Shan Wang, Yong-Gang Ma
A consecutive Sonogashira coupling reaction, acetylene hydroamination cyclization of 2-(2-bromophenyl)quinazolin-4(3H)-ones and terminal alkynes, is described catalyzed by CuI/l-proline in the presence of Cs2CO3. This procedure provided a facile method for the synthesis of isoindolo[1,2-b]quinazolin-10(12H)-one derivatives in good yields.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00259

DOI: 10.1021/acs.joc.7b00259

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