Dietary Carbohydrates Impair Healthspan and Promote Mortality
The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.
Publisher URL: http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30562-4
DOI: 10.1016/j.cmet.2017.09.011
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