5 years ago

Functional Built-In Template Directed Siliceous Fluorescent Supramolecular Vesicles as Diagnostics

Functional Built-In Template Directed Siliceous Fluorescent Supramolecular Vesicles as Diagnostics
Ben Zhong Tang, Jianbin Huang, Markus Drechsler, Kaerdun Liu, Fan Bai, Ruoyan Li, Jie Li, Hengyu Chen, Yun Yan
Functional template directed synthesis of hybrid siliceous fluorescent vesicle (HSFV) is fabricated by using fluorescent vesicle as a built-in template. The template vesicle is the ionic self-assembly of an aggregation-induced emission (AIE) fluorogen. Upon depositing folic acid modified silica shell on its surface, the obtained HSFVs display low cytotoxicity, significant fluorescence, and targeted drug delivery toward cancer cells. Furthermore, the wall-thickness of the HSFVs can be controlled via altered concentration of silica source. This is the first report of HSFV employing the template vesicle as a built-in fluorescent agent, which represents a good example of rational design for an effective diagnostics, and may open up a new avenue for precision medicine.

Publisher URL: http://dx.doi.org/10.1021/acsami.7b06306

DOI: 10.1021/acsami.7b06306

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