5 years ago

Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal GALT Immune Reconstitution in HIV-infected Patients Initiating Antiretroviral Therapy.

Landay, Ma, Serrano-Villar, Utay, Sainz, Thompson, Kashuba, Garcia, Mann, Miller, Chun, Asmuth, Pollard, Troia-Cancio
Plasma, duodenal, and rectal tissue antiretroviral therapy drug concentrations, HIV-RNA and HIV-DNA copy numbers, and recovery of mucosal immunity were measured before and 9-months after initiation of 3 different antiretroviral therapy regimens in 26 subjects. Plasma and tissue HIV-RNA correlated at baseline and when 9-month declines were compared, suggesting that these compartments are tightly associated. Antiretroviral tissue:blood penetration ratios were above the IC50 values in almost 100% of cases. There were no correlations between drug concentrations and HIV DNA/RNA. Importantly, no evidence was found for residual viral replication or deficient tissue drug penetration to account for delayed GALT immune recovery.

Publisher URL: http://doi.org/10.1093/infdis/jix418

DOI: 10.1093/infdis/jix418

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