Organic Letters
Organic Letters
5 years ago

Visible-Light-Mediated Construction of Pyrroloindolines via an Amidyl Radical Cyclization/Carbon Radical Addition Cascade: Rapid Synthesis of (±)-Flustramide B

Visible-Light-Mediated Construction of Pyrroloindolines via an Amidyl Radical Cyclization/Carbon Radical Addition Cascade: Rapid Synthesis of (±)-Flustramide B
Ting Wang, Yuliu Du, Kui Wu
The development of visible-light-mediated synthesis of pyrroloindolines via an amidyl radical cyclization–carbon radical functionalization cascade is reported. The transformation shows a broad substrate scope, tolerating a variety of substitutions on indole aromatic rings and N-centers. Different functionalized alkene systems could be used as radical acceptors. Relying on this strategy, a rapid synthesis of flustramide B was achieved.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02837

DOI: 10.1021/acs.orglett.7b02837

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