5 years ago

Enhanced Biocompatibility in Anodic TaO x Nanotube Arrays

Her-Hsiung Huang, Yen-Bin Hsu, Kuan-Wen Wang, Yu-Jin Zeng, Sheng-Wei Lee, Chien-Ying Wang, Sheng-Chen Twan, Ming-Ying Lan


This study first investigates the biocompatibility of self-organized TaO x nanotube arrays with different nanotube diameters fabricated by electrochemical anodization. All as-anodized TaO x nanotubes were identified to be an amorphous phase. The transition in surface wettability with TaO x nanotube diameters can be explained based on Wenzel’s model in terms of geometric roughness. In vitro biocompatibility evaluation further indicates that fibroblast cells exhibit an obvious wettability-dependent behavior on the TaO x nanotubes. The 35-nm-diameter TaO x nanotube arrays reveal the highest biocompatibility among all samples. This enhancement could be attributed to highly dense focal points provided by TaO x nanotubes due to higher surface hydrophilicity. This work demonstrates that the biocompatibility in Ta can be improved by forming TaO x nanotube arrays on the surface with appropriate nanotube diameter and geometric roughness.

Publisher URL: https://link.springer.com/article/10.1186/s11671-017-2325-0

DOI: 10.1186/s11671-017-2325-0

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