Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

General, Mild, and Metal-Free Synthesis of Phenyl Selenoesters from Anhydrides and Their Use in Peptide Synthesis

General, Mild, and Metal-Free Synthesis of Phenyl Selenoesters from Anhydrides and Their Use in Peptide Synthesis
Carlo Siciliano, Andrea Temperini, Francesca Piazzolla, Lucio Minuti, Massimo Curini
A mild, practical, and simple procedure for phenyl selenoesters synthesis from several anhydrides and diphenyl diselenide was developed. This transition-metal-free method provides a straightforward entry to storable Fmoc-amino acid selenoesters which are effective chemoselective acylating reagents. An application to oligopeptide synthesis was illustrated.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00173

DOI: 10.1021/acs.joc.7b00173

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