Chemical Science
Chemical Science
5 years ago

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(II) catalyst

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(II) catalyst
Yuteng Wu, Terence T.-L. Kwan, David R. Spring, Hannah F. Sore, Goncalo J. L. Bernardes, Fengzhi Zhang, Elizabeth C. Frye, Stephen J. Walsh, Stephen Wallace, Martin Welch, Warren R. J. D. Galloway, Jason W. Chin, Omar Boutureira, Moni K. Gupta
The development of site-specific modification of alkyne-functionalized proteins using dimethylarylsilanes and substoichiometric or low-loading of Ru(II) catalysts is reported. Furthermore, the resultant gem-vinylsilane can undergo further targeted chemical modifications, highlighting its potential for single-site, dual-modification applications.

Publisher URL: http://feeds.rsc.org/~r/rss/SC/~3/bqQTKzByRNM/C6SC05313K

DOI: 2017/SC/C6SC05313K

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.