3 years ago

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(II) catalyst

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(II) catalyst
Yuteng Wu, Terence T.-L. Kwan, David R. Spring, Hannah F. Sore, Goncalo J. L. Bernardes, Fengzhi Zhang, Elizabeth C. Frye, Stephen J. Walsh, Stephen Wallace, Martin Welch, Warren R. J. D. Galloway, Jason W. Chin, Omar Boutureira, Moni K. Gupta
The development of site-specific modification of alkyne-functionalized proteins using dimethylarylsilanes and substoichiometric or low-loading of Ru(II) catalysts is reported. Furthermore, the resultant gem-vinylsilane can undergo further targeted chemical modifications, highlighting its potential for single-site, dual-modification applications.

Publisher URL: http://feeds.rsc.org/~r/rss/SC/~3/bqQTKzByRNM/C6SC05313K

DOI: 2017/SC/C6SC05313K

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