Current Medicinal Chemistry
Current Medicinal Chemistry
5 years ago

Circulating microRNAs: valuable biomarkers for diagnosis and prognosis of gastric cancer.

Kazemi, Shekari, Baradaran, Shanehbandi
Gastric cancer (GC) as a global health problem is one of the deadliest cancer all over the world. Poor clinical symptoms, unfavorable prognosis and absence of proper diagnostic techniques for early detection cause GC as the third lethal cancer in the world. Presence of sensitive and specific biomarkers for early detection and monitoring the progression of GC could lead to the reduction of mortality. MicroRNAs (miRNAs) are gene regulator RNAs play important roles in tumorgenesis. In addition to intracellular miRNAs, circulating miRNAs faithfully reflect the state of cancer progression and provide a promising perspective on early diagnosis of GC. High stability and a significant relationship of circulating miRNAs with the patho-physiological status of GC progression suggested them as ideal biomarkers instead of invasive methods. With the advent of novel research tools for studying circulating miRNAs, the numbers of studies are growing. However, despite their exclusive properties as potential biomarkers, accumulating evidences indicate widespread inconsistencies between reports which illustrates the need for precise evaluating previous studies and standardization of detection protocols. Here, we reviewed comprehensively the latest studies and restrictive barriers of clinical usage of circulating miRNAs as diagnosis and or prognosis biomarkers in GC.

Publisher URL: http://doi.org/10.2174/0929867324666171003123425

DOI: 10.2174/0929867324666171003123425

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