3 years ago

Is periodontitis associated with halitosis? A systematic review and meta-regression analysis

Mariana G. Cademartori, Flávio F. Demarco, Rodrigo López, Manuela F. Silva, Gustavo G. Nascimento, Fábio R. M. Leite
Aim To systematically review the literature in order to investigate a potential association between periodontitis and halitosis. Methods Electronic searches were performed in four different databases: PubMed, Scopus, Web of Science and Scielo. Population-based observational studies that tested the association between periodontitis and halitosis were included. Additionally, meta-analysis, meta-regression and subgroup analyses were performed to synthesize the evidence. Results A total of 1,107 articles were identified in electronic searches; out of which, five were included within the meta-analysis. Pooled estimates revealed that individuals with periodontitis presented 3.16 times higher odds (OR 3.16; 95% CI: 1.12–8.95) of having halitosis. Meta-regression and subgroups analyses showed that criteria used for halitosis and periodontitis assessment explained nearly 45% and 24% of heterogeneity between studies, respectively. Conclusions Positive association between periodontitis and halitosis was found in pooled results of population-based observational studies. However, this evidence is derived from cross-sectional studies.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jcpe.12786

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