Analytical Chemistry
Analytical Chemistry
5 years ago

Quantitative Determination of the Differential Raman Scattering Cross Sections of Glucose by Femtosecond Stimulated Raman Scattering

Quantitative Determination of the Differential Raman Scattering Cross Sections of Glucose by Femtosecond Stimulated Raman Scattering
Richard P. Van Duyne, George C. Schatz, Michael R. Wasielewski, Brian T. Phelan, Ryan M. Young, Michael O. McAnally
Femtosecond stimulated Raman spectroscopy (FSRS) is a vibrational spectroscopy technique that has been used in a wide variety of applications: from transient vibrational signature tracking to amplifying weak normal Raman scattering signals. Presented here is an application of FSRS to quantify the differential Raman scattering cross sections (DRSCs) of glucose. In using FSRS to determine the DRSCs of multiple glucose vibrational modes, we demonstrate the applicability of both stimulated Raman loss (SRL) spectroscopy and stimulated Raman gain (SRG) FSRS. Using the two analogous FSRS techniques, SRG and SRL, we determine that the DRSCs of glucose excited at 514.5 nm range from a low of 5.0 ± 1.1 × 10–30 to a high of 8.9 ± 0.9 × 10–30 cm2 molecule–1 sr–1. This work establishes both the compatibility of SRL for measuring DRSCs and values for the DRSC of multiple vibrational modes of glucose.

Publisher URL: http://dx.doi.org/10.1021/acs.analchem.7b01335

DOI: 10.1021/acs.analchem.7b01335

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