4 years ago

Simultaneous Online Monitoring of Multiple Reactions Using a Miniature Mass Spectrometer

Simultaneous Online Monitoring of Multiple Reactions Using a Miniature Mass Spectrometer
Tawnya G. Flick, R. Graham Cooks, Heather L. Osswald, Stephen T. Ayrton, Dalton T. Snyder, Christopher J. Pulliam, Patrick W. Fedick, Ryan M. Bain
Advances in chemical sampling using miniature mass spectrometer technology are used to monitor slow reactions at a frequency of ca. 180 h–1 (on the Mini 12) with no sample carryover and with inline derivatization in the case of poorly ionizing compounds. Moreover, we demonstrate high reproducibility with a relative error of less than 10% for major components. Monitoring is enabled using a continuous-flow nanoelectrospray (CF-nESI) probe contained in a custom-built 3D-printed rotary holder. The holder position is automatically set using a stepper motor controlled by a microcontroller. Reaction progress of up to six reactions, including hydrazone formation and Katritzky transamination, can be monitored simultaneously without carryover for several hours.

Publisher URL: http://dx.doi.org/10.1021/acs.analchem.7b00119

DOI: 10.1021/acs.analchem.7b00119

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