Chemistry of Materials
Chemistry of Materials
5 years ago

Aptamer-Functionalized Hydrogel for Self-Programmed Protein Release via Sequential Photoreaction and Hybridization

Aptamer-Functionalized Hydrogel for Self-Programmed Protein Release via Sequential Photoreaction and Hybridization
Nan Zhao, Yong Wang, Pinliang Jiang, Jinping Lai, Lidya Abune, Erin R. Gaddes
A dynamic hydrogel that sequentially responds to two independent but interrelated physical and biomolecular signals was reported in this work. Once hit by an external light signal, an immobilized internal molecular signal is activated and freed via photoreaction; and subsequently the freed molecular signal works as a self-programming factor of the hydrogel to induce the dissociation of a biomolecular complex to release protein via a hybridization reaction. Notably, pulsatile external light input can be converted to periodical protein output from the hydrogel to regulate cell migration. Thus, this hydrogel holds potential as a self-programming platform for biological and biomedical applications such as controlled release of bioactive substances.

Publisher URL: http://dx.doi.org/10.1021/acs.chemmater.7b00875

DOI: 10.1021/acs.chemmater.7b00875

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.