Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Total Synthesis of Lamellarin D Trimethyl Ether, Lamellarin D, and Lamellarin H

Total Synthesis of Lamellarin D Trimethyl Ether, Lamellarin D, and Lamellarin H
Prathama S. Mainkar, Amit B. Pawar, Srivari Chandrasekhar, Dhanaji M. Lade
Total syntheses of three different lamellarins have been accomplished using a Ru(II)-catalyzed (3 + 2) annulation strategy to construct the central pyrrole ring. The striking features of this synthesis are the use of PEG-400 as a green solvent for the (3 + 2) annulation reaction and multiple catalytic reactions with excellent overall yield. The present route also enables the synthesis of various lamellarin analogues devoid of a B ring.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00636

DOI: 10.1021/acs.joc.7b00636

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