5 years ago

Human Pulmonary 3D Models For Translational Research

Human Pulmonary 3D Models For Translational Research
Katja Zscheppang, Norbert Suttorp, Johanna Berg, Stefan Hippenstiel, Darcy E. Wagner, Andreas C. Hocke, Sarah Hedtrich, Leonie Verheyen
Lung diseases belong to the major causes of death worldwide. Recent innovative methodological developments now allow more and more for the use of primary human tissue and cells to model such diseases. In this regard, the review covers bronchial air-liquid interface cultures, precision cut lung slices as well as ex vivo cultures of explanted peripheral lung tissue and de-/re-cellularization models. Diseases such as asthma or infections are discussed and an outlook on further areas for development is given. Overall, the progress in ex vivo modeling by using primary human material could make translational research activities more efficient by simultaneously fostering the mechanistic understanding of human lung diseases while reducing animal usage in biomedical research. Illustration of the different requirements and achievements (first and second level) for different types of 3D human pulmonary models (third level), which then can be applied in different methodological modalities and read-out systems (fourth level) to give insight in toxicological, functional, or disease related aspects (fifth level).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/biot.201700341

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