Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Cytoprotective Encapsulation of Individual Jurkat T Cells within Durable TiO2 Shells for T-Cell Therapy

Cytoprotective Encapsulation of Individual Jurkat T Cells within Durable TiO2 Shells for T-Cell Therapy
Matthew Park, Mi-Hee Kim, Wongu Youn, Eun Hyea Ko, Vadim G. Kessler, Insung S. Choi, Gulaim A. Seisenbaeva, Daewha Hong
Cell-in-shell structures, also known as artificial spores, have great potential in nanomedicine because of their enhanced viability during in vitro manipulation and storage. In their Communication (DOI: 10.1002/anie.201703886), I. S. Choi, V. Kessler, D. Hong, et al. report that Jurkat T cells maintain their therapeutically relevant activities, including antigen–antibody interactions and interleukin-2 secretion, while acquiring enhanced tolerance against harmful stressors, after durable TiO2 shell formation.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201706513

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