5 years ago

Heterocyclic boronic acids display sialic acid selective binding in a hypoxic tumor relevant acidic environment

Heterocyclic boronic acids display sialic acid selective binding in a hypoxic tumor relevant acidic environment
T. Khan, A. J. Stephenson-Brown, Y. Miyahara, H. Cabral, A. Matsumoto, K. Kataoka, T. Miyazawa
A group of heterocyclic boronic acids demonstrating unusually high affinity and selectivity for sialic acids are described, with strong interactions under the weakly acidic pH conditions associated with a hypoxic tumoral microenvironment.

Publisher URL: http://feeds.rsc.org/~r/rss/SC/~3/U9H8ZvLw57U/C7SC01905J

DOI: 2017/SC/C7SC01905J

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