Chemical Reviews
Chemical Reviews
5 years ago

Ligand-Promoted Palladium-Catalyzed Aerobic Oxidation Reactions

Ligand-Promoted Palladium-Catalyzed Aerobic Oxidation Reactions
Paul B. White, Adam B. Weinstein, Dian Wang, Shannon S. Stahl
Palladium-catalyzed aerobic oxidation reactions have been the focus of industrial application and extensive research efforts for nearly 60 years. A significant transition occurred in this field approximately 20 years ago, with the introduction of catalysts supported by ancillary ligands. The ligands play crucial roles in the reactions, including promotion of direct oxidation of palladium(0) by O2, bypassing the typical requirement for Cu salts or related redox cocatalysts to facilitate oxidation of the reduced Pd catalyst; facilitation of key bond-breaking and bond-forming steps during substrate oxidation; and modulation of chemo-, regio-, or stereoselectivity of a reaction. The use of ligands has contributed to significant expansion of the scope of accessible aerobic oxidation reactions. Increased understanding of the role of ancillary ligands should promote the development of new synthetic transformations, enable improved control over the reaction selectivity, and improve catalyst activity and stability. This review surveys the different ligands that have been used to support palladium-catalyzed aerobic oxidation reactions and, where possible, describes mechanistic insights into the role played by the ancillary ligand.

Publisher URL: http://dx.doi.org/10.1021/acs.chemrev.7b00334

DOI: 10.1021/acs.chemrev.7b00334

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