Guardians of the ERAD Galaxy
The endoplasmic reticulum-associated degradation (ERAD) pathway facilitates the disposal of terminally misfolded proteins in the early secretory pathway yet spares folding intermediates from being destroyed. Zhang et al. report on a protein complex that acts as a guardian to protect these folding intermediates from being targeted for ERAD.
Publisher URL: http://www.cell.com/cell/fulltext/S0092-8674(17)31117-0
DOI: 10.1016/j.cell.2017.09.023
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