Molecular Nutrition and Food Research
Molecular Nutrition and Food Research
5 years ago

An isoflavone enriched diet increases skeletal muscle adaptation in response to physical activity in ovariectomized rats

An isoflavone enriched diet increases skeletal muscle adaptation in response to physical activity in ovariectomized rats
Jonas Hengevoß, Mingyong Xie, Wenya Zheng, Sebastian T. Soukup, Patrick Diel, Sabine E. Kulling
Scope This study was to investigate anabolic adaptation of skeletal muscle in response to an isoflavone (ISO) enriched diet, training and their combinations in ovariectomized (OVX) rats. Methods and results Female Wistar rats were sedentary, performed treadmill uphill running, received ISOs, or a combination of ISOs and running after ovariectomy. Body weight was increased by OVX. Both ISO and training treatment antagonized this increase. The weights of soleus and gastrocnemius muscles were increased only when training and ISOs were combined. In soleus muscle insulin-like growth factor (IGF)-1R, MyoD and Myogenin expressions were only up-regulated by training in Sham groups. However, a stimulation of IGF-1R and MyoD expression could be observed when ISOs and training were combined. In gastrocnemius muscle MyoD and Myogenin expressions were stimulated by either training or ISOs. Additive effects were detected when combining the two interventions. Conclusion Our results indicate that the combination of ISOs and exercise is more efficient in increasing relative skeletal muscle mass and the expression of molecular markers related to anabolic adaptation in the skeletal muscle of female rats. Two interventions, soy isoflavone enriched diet and exercise, were used in this animal study with ovariectomized rats. The combination of them was found to affect adaptation of skeletal muscle by increasing the relative skeletal muscle mass and modulating mRNA expression of the molecular markers related to muscle growth (IGF-1, IGF-1R) and myogenesis (MyoD, Myogenin).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/mnfr.201600843

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