3 years ago

Hepatic and renal expression of senescence marker protein-30 and its biological significance.

Fujita, Kitamura, Shirasawa, Maruyama, Inoue
A novel rat hepatic protein was detected and isolated, the amount of which is down-regulated in an androgen-independent manner with ageing. This protein was designated as senescence marker protein-30 (SMP30). Senescence marker protein-30 turned out to be identical to a hepatic calcium-binding protein called regucalcin (RC). This review gives an overview of SMP30 in its structure, expression and possible physiological function(s). A hypothetical role of SMP30 in ageing and calcium homeostasis is also discussed.

Publisher URL: http://doi.org/10.1111/jgh.1998.13.s1.124

DOI: 10.1111/jgh.1998.13.s1.124

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