Organic Letters
Organic Letters
5 years ago

Nickel-Catalyzed Amination of Aryl 2-Pyridyl Ethers via Cleavage of the Carbon–Oxygen Bond

Nickel-Catalyzed Amination of Aryl 2-Pyridyl Ethers via Cleavage of the Carbon–Oxygen Bond
Jing Li, Zhong-Xia Wang
Reaction of aryl 2-pyridyl ethers with amines was carried out via Ni-catalyzed C–OPy bond cleavage, giving aniline derivatives in reasonable to excellent yields. Both electron-rich and electron-poor aryl 2-pyridyl ethers and a wide range of amines can be used in the transformation. The method provides a conversion way for the 2-pyridyloxy directing group in the C–H bond functionalization reactions.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01549

DOI: 10.1021/acs.orglett.7b01549

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