3 years ago

Assessing the protective effect of bentonite against lead toxicity in growing lambs

Samira Azadbakht, Ali Akbar Khadem, Mohammad Ali Norouzian

Abstract

The objective of the present experiment was to investigate the effect of bentonite supplementation in lead (Pb)-exposed lambs on serum Pb, Ca, P, Cu, Zn, and Fe concentrations, blood hematological parameters, and hepatic enzymes. Twenty Zandi male lambs (initial BW, 17.5 ± 1.6 kg) were randomly assigned to one of the four treatments: (1) control (no Pb or bentonite), (2) 15 mg/kg DM Pb as Pb acetate with no bentonite, (3) 15 mg/kg DM Pb as Pb acetate with 1.5% bentonite, and (4) 15 mg/kg DM Pb as Pb acetate with 3% bentonite. The experiment lasted after 90 days. Lead intake resulted in a decrease (P < 0.05) in serum Fe and an increase in serum Pb, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activities (P < 0.05). Bentonite supplementation at 1.5 or 3% of DM decreased blood Pb concentration (P < 0.01) in lambs fed diets containing Pb and reduced (P < 0.05) blood concentration of Cu and Zn compared to control group (P < 0.01). However, the hematological parameters were not affected by any of the treatments. Our results showed that the dietary supplementation of bentonite could protect lambs against lead toxicity.

Publisher URL: https://link.springer.com/article/10.1007/s11356-017-0345-z

DOI: 10.1007/s11356-017-0345-z

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