5 years ago

Copper-Catalyzed Imidovinylation of Alkynes via 1,3-Vinyl Migration

Copper-Catalyzed Imidovinylation of Alkynes via 1,3-Vinyl Migration
Qian Zhang, Yimin Wang, Shengbiao Yang, Qiao Zhang, Guangfan Zheng, Yan Li, Jiaqiong Sun
The first copper-catalyzed imidovinylation of alkynes has been developed, which grants facile access to various (E)-2-imido-2,4-dienals with high stereoselectivity under mild conditions. This transformation also represents the first 1,3-carbon migration of propargylic alcohols and their derivatives.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01599

DOI: 10.1021/acs.orglett.7b01599

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