3 years ago

Evolution of Alu Subfamily Structure in the Saimiri Lineage of New World Monkeys.

Phillippe, Batzer, Konkel, Denham, Vanchiere, Baker, St Romain, Walker, Mierl, Gonzalez-Quiroga
Squirrel monkeys, Saimiri, are commonly found in zoological parks and used in biomedical research. S. boliviensis is the most common species for research; however, there is little information about genome evolution within this primate lineage. Here, we reconstruct the Alu element sequence amplification and evolution in the genus Saimiri at the time of divergence within the family Cebidae lineage. Alu elements are the most successful SINE (Short Interspersed Element) in primates. Here, we report 46 Saimiri lineage specific Alu subfamilies. Retrotransposition activity involved subfamilies related to AluS, AluTa10, and AluTa15. Many subfamilies are simultaneously active within the Saimiri lineage, a finding which supports the stealth model of Alu amplification. We also report a high resolution analysis of Alu subfamilies within the S. boliviensis genome [saiBol1].

Publisher URL: http://doi.org/10.1093/gbe/evx172

DOI: 10.1093/gbe/evx172

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