Journal of the American Chemical Society
Journal of the American Chemical Society
5 years ago

Highly Enantioselective Cobalt-Catalyzed Hydrosilylation of Alkenes

Highly Enantioselective Cobalt-Catalyzed Hydrosilylation of Alkenes
Xinpeng Cheng, Heyi Zhang, Biao Cheng, Zhan Lu, Peng Lu
A cobalt-catalyzed highly Markovnikov-type and enantioselective hydrosilylation of alkenes is developed for the efficient synthesis of valuable chiral dihydrosilanes. This protocol is operationally simple and atom-economy, and using relatively simple and readily available starting materials. The reaction is suitable for both aryl and aliphatic alkenes with excellent functional group tolerability. The reaction could be easily carried out in a gram-scale. The TOF and TON is up to 1800 and 860, respectively.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b04137

DOI: 10.1021/jacs.7b04137

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