3 years ago
Transformable Sulfoximine Assisted One-Pot Double Annulation of Vinylic C–H Bonds with Unactivated Alkynes
Tirumaleswararao Guntreddi, Akhila K. Sahoo, E. Ramesh, Majji Shankar
The methylphenyl sulfoximine (MPS) directing group (DG) successfully promotes the one-pot double annulation of acrylic acids with alkynes under Ru catalysis, which is unprecedented. Diverse arrays of pyrido-fused-isoquinolinone skeletons are fabricated from acrylamides, creating two C–C and two C–N bonds in a single operation. The unsymmetrical annulation with two distinct alkynes is presented. The recovery of methylphenyl sulfoxide, a precursor of MPS, validates the synthetic adaptability of transformable-DG (TfDG) in C–H activation.
Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02824
DOI: 10.1021/acs.orglett.7b02824
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