3 years ago

Self-Assembly Behavior and Biocompatible Cross-Linking of Double Hydrophilic Linear-Brush Block Copolymers

Self-Assembly Behavior and Biocompatible Cross-Linking of Double Hydrophilic Linear-Brush Block Copolymers
Jochen Willersinn, Bernhard V. K. J. Schmidt, Noah Al Nakeeb
The self-assembly of a novel double hydrophilic block copolymer (DHBC) architecture is presented. By combining linear biomacromolecule pullulan with biocompatible poly(oligo(ethylene glycol) methyl ether) methacrylate) (P(OEGMA))-brush blocks via copper(I) catalyzed azide alkyne cycloaddition, a novel DHBC linear-brush combination is obtained. Self-assembly in water was observed via optical microscopy and dynamic light scattering (DLS). Moreover, DLS investigations showed that self-assembly efficiency significantly relies on the degree of polymerization of the brush-block. Furthermore, the self-assembly of the formed particles was investigated with cryogenic scanning electron microscopy (cryo-SEM). To preserve the aggregates at lower concentrations, a biocompatible and FDA approved cross-linking agent, namely, sodium trimetaphosphate (STMP), was utilized for cross-linking. The reaction of STMP and pullulan was followed by 31P NMR, while the presence of the cross-linking agent within the particles could be detected via the combination cryo-SEM and energy dispersive X-ray spectroscopy.

Publisher URL: http://dx.doi.org/10.1021/acs.biomac.7b01094

DOI: 10.1021/acs.biomac.7b01094

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