3 years ago

Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair

Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair
Kay Diederichs, Michiko Kimoto, Andreas Marx, Karin Betz, Ichiro Hirao
Expansion of the genetic alphabet with hydrophobic artificial base pairs holds great promise for future applications. In their Communication (DOI: 10.1002/anie.201704190), A. Marx, I. Hirao, and co-workers report a high-resolution crystal structure of the dDs–dPx pair in the confines of a DNA polymerase and show that the artificial pair adopts a planar structure just like a natural nucleobase pair. Its varying size and shape, however, cause minor alterations near the active site.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201706478

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