5 years ago

Aberrant default-mode network-hippocampus connectivity after sad memory-recall in remitted-depression.

van Wingen, Schene, Martens, Figueroa, Ruhé, Mocking
Rumination and cognitive reactivity (dysfunctional cognitions after sad mood-induction) remain high in remitted Major Depressive Disorder (MDD) and can contribute to new episodes. These factors have been linked to increased fMRI resting-state functional-connectivity within the Default-Mode Network (DMN). It remains unclear whether (I) increased DMN-connectivity persists during MDD-remission, and (II) whether sad mood-induction differentially affects DMN-connectivity in remitted-MDD versus controls. Moreover, DMN-connectivity studies in remitted-MDD were previously confounded by antidepressant-use. Sixty-two MDD-patients remitted from ≥2 episodes, psychotropic-medication free, and 41 controls, participated in two 5-minute neutral and sad mood-inductions by autobiographical-recall and neutral/sad music, each followed by 8-minutes resting-state fMRI-scanning. We identified DMN-components using Independent Component Analysis and entered subject- and sessions-specific components into a repeated measures analysis of variance. Connectivity-differences were extracted and correlated with baseline cognitive reactivity and rumination as measures of vulnerability for recurrence. After sad vs. neutral mood-induction, controls, but not remitted-MDD, showed an increase in connectivity between the posterior-DMN and a cluster consisting mostly of the hippocampus (p = 0.006). Less posterior-DMN-hippocampal connectivity was associated with higher cognitive reactivity (r= -0.21, p = 0.046) and rumination (r= -0.27, p = 0.017). After recalling sad autobiographical-memories, aberrant posterior-DMN-hippocampal connectivity, associated with cognitive reactivity and rumination, remains a neural vulnerability in MDD-remission.

Publisher URL: http://doi.org/10.1093/scan/nsx108

DOI: 10.1093/scan/nsx108

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