5 years ago

Intramolecular Chirality Transfer [2 + 2] Cycloadditions of Allenoates and Alkenes

Intramolecular Chirality Transfer [2 + 2] Cycloadditions of Allenoates and Alkenes
Young J. Hong, Yao Xu, M. Kevin Brown, Dean J. Tantillo
Intramolecular chirality transfer [2 + 2] cycloaddition of enantiomerically enriched allenoates and alkenes is presented. The use of a chiral catalyst was found to be critical to achieve high levels of diastereoselectivity compared to use of an achiral catalyst. The method developed leads to highly substituted cyclobutanes that would be difficult to prepare by alternative methods.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01420

DOI: 10.1021/acs.orglett.7b01420

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