5 years ago

Biocatalysed olefin reduction of 3-alkylidene oxindoles by baker's yeast

Biocatalysed olefin reduction of 3-alkylidene oxindoles by baker's yeast
3-Substituted oxindoles are very interesting molecules both for their potential biological activity and for their role as starting materials toward more complex oxindole-based structures. These molecules can be prepared by the reduction of a 3-ylidene oxindole precursor by classical metal-catalysed chemical reductions of the olefin. In this work we present a biocatalytic approach for the reduction of oxindole-based olefins using baker's yeast. All the substrates were efficiently reduced in high yields. When an α,β-unsaturated ketone was used, the corresponding saturated alcohol was obtained in high yield and ee. To further investigate the enzyme-substrate interactions a molecular docking study was also performed.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017306415

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