Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
4 years ago

Synthetic Approaches to the New Drugs Approved During 2015

Synthetic Approaches to the New Drugs Approved During 2015
Carolyn A. Leverett, Kevin K. -C. Liu, Christopher J. O’Donnell, Hong X. Ding, Sarah J. Fink, Andrew C. Flick, Robert E. Kyne
New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-scale synthetic approaches to 29 new chemical entities (NCEs) that were approved for the first time in 2015.

Publisher URL: http://dx.doi.org/10.1021/acs.jmedchem.7b00010

DOI: 10.1021/acs.jmedchem.7b00010

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