5 years ago

Objectively Measured Physical Activity, Sedentary Behavior and Genetic Predisposition to Obesity in US Hispanics/Latinos: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Argos, North, Gellman, Kaplan, Sotres-Alvarez, Isasi, Moon, Cai, Sofer, Qi, Wang, Moncrieft
Studies using self-reported data suggest gene-physical activity interaction on obesity, yet the influence of sedentary behavior, distinct from lack of physical activity, on genetic associations with obesity remains unclear. We analyzed interactions of accelerometer-measured moderate-to-vigorous physical activity (MVPA) and sedentary time with genetic variants on obesity among 9,645 US Hispanics/Latinos. An overall genetic risk score (GRS), central nervous system (CNS)-related GRS, and non-CNS GRS were calculated based on 97 BMI-associated SNPs. Genetic association with BMI was stronger in individuals with lower MVPA (1(st) tertile) versus higher MVPA (3(rd) tertile) (β=0.78 [0.10] vs 0.39 [0.10] kg/m(2) per standard deviation increment of GRS; Pinteraction=0.005), and in those with greater sedentary time (3(rd) tertile) versus less sedentary time (1(st) tertile) (β=0.73 [0.10] vs 0.44 [0.10] kg/m(2); Pinteraction=0.006). Similar significant interaction patterns were observed for obesity risk, body fat mass, fat percentage, fat mass index, and waist circumference, but not with fat free mass. The CNS GRS, but not the non-CNS GRS, showed significant interactions with MVPA and sedentary behavior on BMI and other adiposity traits. Our data suggest that both increasing physical activity and reducing sedentary behavior may attenuate genetic associations with obesity, though the independence of these interaction effects needs further investigation.

Publisher URL: http://doi.org/10.2337/db17-0573

DOI: 10.2337/db17-0573

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