3 years ago

Diversity-oriented synthesis of 1,3-benzodiazepines

Diversity-oriented synthesis of 1,3-benzodiazepines
A concise assembly of the 1,3-benzodiazepine core from A3-coupling-derived propargylamines and ortho-bromophenylisocyanates is described. The developed synthetic sequence involves the addition of propargylamine to isocyanate followed by palladium-catalyzed intramolecular alkyne hydroarylation that could be accomplished in a stepwise or one-pot manner.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017309638

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