4 years ago

Copper-Catalyzed Cyanation of N-Tosylhydrazones with Thiocyanate Salt as the “CN” Source

Copper-Catalyzed Cyanation of N-Tosylhydrazones with Thiocyanate Salt as the “CN” Source
Xianwei Li, Yue Yu, Huanfeng Jiang, Wanqing Wu, Yubing Huang, Jinghe Cen, Chuanle Zhu, Zhongzhi Zhu
A novel protocol for the synthesis of α-aryl nitriles has been successfully achieved via a copper-catalyzed cyanation of N-tosylhydrazones employing thiocyanate as the source of cyanide. The features of this method include a convenient operation, readily available substrates, low-toxicity thiocyanate salts, and a broad substrate scope.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00836

DOI: 10.1021/acs.joc.7b00836

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