Biomacromolecules
Biomacromolecules
5 years ago

Ultrafast SET-LRP with Peptoid Cytostatic Drugs as Monofunctional and Bifunctional Initiators

Ultrafast SET-LRP with Peptoid Cytostatic Drugs as Monofunctional and Bifunctional Initiators
Samuel E. Sherman, Rauan Smail, Mojtaba Enayati, Gerard Lligadas, Silvia Grama, Virgil Percec
To continue expanding the use of Single Electron Transfer-Living Radical Polymerization (SET-LRP) in applications at the interface between macromolecular science, biomacromolecules, biology and medicine, it is essential to develop novel initiators that do not compromise the structural stability of synthesized polymers in biological environments. Here, we report that stable 2-bromopropionyl peptoid-type initiators such as 1,4-bis(2-bromopropionyl)piperazine and 4-(2-bromopropionyl)morpholine are an alternative that meets the standards reached by the well-known secondary and tertiary α-haloester-type initiators in terms of excellent control over molecular weight evolution and distribution as well as polymer chain ends. SET-LRP methodologies in organic, aqueous, and biphasic organic–aqueous media were evaluated for this purpose.

Publisher URL: http://dx.doi.org/10.1021/acs.biomac.7b00722

DOI: 10.1021/acs.biomac.7b00722

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