American Journal of Transplantation
American Journal of Transplantation
5 years ago

Invited letter in response to “Predicted indirectly recognizable HLA epitopes (PIRCHE): only the tip of the iceberg?”

Nils Lachmann, Petra Reinke, Danilo Schmidt, Matthias Niemann, Eric Spierings, Constanze Schönemann, Axel Pruß, Klemens Budde, Oliver Staeck, Fabian Halleck
We thank Guidicelli et al. for sharing their valuable thoughts on our recent publication (1) and appreciate the suggestions and ideas for further improvements of PIRCHE-matching (2). Missing consideration of some allopeptides is a limitation of the version of PIRCHE used in this study. The latest version takes more HLA allopeptide sources into account (e.g. DQA1, DPA1 and more) which hopefully increases the predictive power of the algorithm. However, this feature could not be applied in our retrospective study, as the present dataset is incomplete for DQA and DP typings. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/ajt.14535

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.