5 years ago

Invited letter in response to “Predicted indirectly recognizable HLA epitopes (PIRCHE): only the tip of the iceberg?”

Nils Lachmann, Petra Reinke, Danilo Schmidt, Matthias Niemann, Eric Spierings, Constanze Schönemann, Axel Pruß, Klemens Budde, Oliver Staeck, Fabian Halleck
We thank Guidicelli et al. for sharing their valuable thoughts on our recent publication (1) and appreciate the suggestions and ideas for further improvements of PIRCHE-matching (2). Missing consideration of some allopeptides is a limitation of the version of PIRCHE used in this study. The latest version takes more HLA allopeptide sources into account (e.g. DQA1, DPA1 and more) which hopefully increases the predictive power of the algorithm. However, this feature could not be applied in our retrospective study, as the present dataset is incomplete for DQA and DP typings. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/ajt.14535

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