3 years ago

Prospective MRI score to predict negative EULAR response in patients with rheumatoid arthritis (RA) before therapy-escalation to a biological therapy

Dear Editor

We read with great interest the article by Baker et al1 who showed that early MRI measures independently predict erosive progression on X-ray and MRI after 1 and 2 years in therapy-naive patients with rheumatoid arthritis (RA) from the randomised-controlled GO-BEFORE trial. Due to these findings, we re-evaluated MRI data from the German REMISSION-PLUS Cohort2 3 at our centre to verify if a MRI score may predict negative response in patients with RA before therapy-escalation to a biological therapy. MRI was performed in 257 patients before therapy-escalation (T0) and after 12 months (T1) and analysed by using the Outcome Measures in Rheumatology (OMERACT) rheumatoid arthritis MRI score (RAMRIS). In addition, clinical and laboratory parameters (Disease Activity Score 28 (DAS-28) and C-reactive protein (CRP)) were collected for each visit. Logistic regression combining clinical and MRI parameters was performed resulting in a combination of the...

Publisher URL: http://ard.bmj.com/cgi/content/short/76/11/e44

DOI: 10.1136/annrheumdis-2017-211257

You might also like
Never Miss Important Research

Researcher is an app designed by academics, for academics. Create a personalised feed in two minutes.
Choose from over 15,000 academics journals covering ten research areas then let Researcher deliver you papers tailored to your interests each day.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.