Journal of the American Chemical Society
Journal of the American Chemical Society
5 years ago

Phenylalanine Increases Membrane Permeability

Phenylalanine Increases Membrane Permeability
Russell Perkins, Veronica Vaida
Biological membranes are a crucial aspect of living systems, controlling the organization and distribution of different chemical components. Control of membrane permeability is especially important for processes such as electron transport in metabolism and signal propagation in nerve cells. In this work, we show that the amino acid phenylalanine produces increased membrane permeability, which is likely responsible for some of the deleterious symptoms associated with high biological phenylalanine concentrations that occur with the genetic disorder phenylketonuria.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b09219

DOI: 10.1021/jacs.7b09219

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