3 years ago

Synthesis of 2,3-Diarylisoindolin-1-one by Copper-Catalyzed Cascade Annulation of 2-Formylbenzonitriles, Arenes, and Diaryliodonium Salts

Synthesis of 2,3-Diarylisoindolin-1-one by Copper-Catalyzed Cascade Annulation of 2-Formylbenzonitriles, Arenes, and Diaryliodonium Salts
Jian Li, Yang Hu, Hui-Ling Sung, Li-Xun Wang, Li Liu, Yang Li, Shu-Hua Bai
A three-component cascade cyclization was developed to synthesize 2,3-diarylisoindolin-1-one by using 2-formylbenzonitrile, arenes, and diaryliodonium salts. The process underwent copper-catalyzed tandem C–N/C–C bond formation, producing isoindolin-1-one derivatives in good to excellent yields.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b02035

DOI: 10.1021/acs.joc.7b02035

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