RutA-Catalyzed Oxidative Cleavage of the Uracil Amide Involves Formation of a Flavin-N5-oxide

4 years ago

RutA-Catalyzed Oxidative Cleavage of the Uracil Amide Involves Formation of a Flavin-N5-oxide

Sanjoy Adak, Tadhg P. Begley

RutA is a novel flavoenzyme on the uracil catabolic pathway that catalyzes uracil ring opening by a unique amide oxidation reaction. Here we provide evidence that this reaction also involves the formation of a flavin-N5-oxide.

Publisher URL: http://dx.doi.org/10.1021/acs.biochem.7b00493

DOI: 10.1021/acs.biochem.7b00493

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