3 years ago

High Relaxivity Gadolinium-Polydopamine Nanoparticles

High Relaxivity Gadolinium-Polydopamine Nanoparticles
Jeffrey D. Rinehart, Zhao Wang, Mauro Botta, Nathan C. Gianneschi, Yiwen Li, Yuran Huang, Yijun Xie, Nanzhi Zang, Sha He, Fabio Carniato
This study reports the preparation of a series of gadolinium-polydopamine nanoparticles (GdPD-NPs) with tunable metal loadings. GdPD-NPs are analyzed by nuclear magnetic relaxation dispersion and with a 7-tesla (T) magnetic resonance imaging (MRI) scanner. A relaxivity of 75 and 10.3 mM−1 s−1 at 1.4 and 7 T is observed, respectively. Furthermore, superconducting quantum interference device magnetometry is used to study intraparticle magnetic interactions and determine the GdPD-NPs consist of isolated metal ions even at maximum metal loadings. From these data, it is concluded that the observed high relaxivities arise from a high hydration state of the Gd(III) at the particle surface, fast rate of water exchange, and negligible antiferromagnetic coupling between Gd(III) centers throughout the particles. This study highlights design parameters and a robust synthetic approach that aid in the development of this scaffold for T1-weighted, high relaxivity MRI contrast agents. A new synthetic method is employed to drastically increase and control the gadolinium loading of polydopamine particles to perform a quantitative investigation on the structure-property relationship of gadolinium-polydopamine nanoparticles MRI agents.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/smll.201701830

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