Cancer Discovery
Cancer Discovery
5 years ago

Checkpoint Inhibitors Spur Changes in Trial Design.

Given the success of checkpoint inhibitors and the desire to test them in combination with other immunotherapies and targeted therapies, hundreds of clinical trials have been launched. To most efficiently study these agents, researchers and the FDA are exploring the use of novel endpoints, the use of new preclinical models, and adaptive trial designs. However, the cost and demands associated with the conduct of increasingly sophisticated early-phase clinical trials are putting smaller companies and some academic medical centers at a disadvantage.

Publisher URL: http://doi.org/10.1158/2159-8290.CD-ND2017-006

DOI: 10.1158/2159-8290.CD-ND2017-006

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