5 years ago

Expanding available pyrazole substitution patterns by sydnone cycloaddition reactions

Expanding available pyrazole substitution patterns by sydnone cycloaddition reactions
We report the use of alkynylsilanes for the regiocontrolled synthesis of pyrazoles from functionalised sydnones. The strategies outlined herein allow a range of pyrazoles to be accessed with substitution patterns that are otherwise not directly obtained with high selectivity by alkyne cycloadditions. Moreover, this study serendipitously highlighted a simple and convenient procedure for the synthesis of aryl monofluoromethyl ethers through the combination of TBAF and dichloromethane.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017304398

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