3 years ago

A New, Short, and Stereocontrolled Synthesis of C2-Symmetric 1,2-Diamines

A New, Short, and Stereocontrolled Synthesis of C2-Symmetric 1,2-Diamines
Nathan C. Wilde, Rajendar Goreti, E. J. Corey, Rajender Vemula
The previously unknown 5-spirocyclohexylisoimidazole has been made efficiently and simply by reaction of ammonia, glyoxal hydrate, and cyclohexanone. It is a very useful precursor for the diastereocontrolled synthesis of many C2-symmetric 1,2-diamines, a class which is important for the generation of a variety of C2-symmetric reagents and catalysts for enantioselective synthesis.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01768

DOI: 10.1021/acs.orglett.7b01768

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