Tetrahedron
Tetrahedron
4 years ago

Preparation of dual responsive low-molecular-weight hydrogel for long-lasting drug delivery

Preparation of dual responsive low-molecular-weight hydrogel for long-lasting drug delivery
A novel low-molecular-weight hydrogel (LMWG) was fabricated by oligopeptide and phenylboronic acid to obtain a smart molecular hydrogel with dual glucose and pH response for long-term drug delivery in this study. Dual glucose and pH responsiveness of the blank molecular hydrogel was first evaluated by on-line tracking the dynamics curves using UV spectroscopy. Model drugs of phenformin for antidiabetes and doxorubicin for anticancer were selected to evaluate the drug carry and glucose/pH responsive drug release of the molecular hydrogel. The results showed the drug-loaded LMWG had good sustaining and long-lasting drug delivery in physiological or pathological environment.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017304416

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